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Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43505
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43505
Synonyms:
4-[4-(4-keto-2-thioxo-1H-quinazolin-3-yl)benzoyl]piperazine-1-carboxylic acid ethyl ester | 4-[oxo-[4-(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)phenyl]methyl]-1-piperazinecarboxylic acid ethyl ester | MLS000095534 | SMR000016980 | cid_3244129 | ethyl 4-[4-(4-oxidanylidene-2-sulfanylidene-1H-quinazolin-3-yl)phenyl]carbonylpiperazine-1-carboxylate | ethyl 4-[4-(4-oxo-2-sulfanylidene-1H-quinazolin-3-yl)benzoyl]piperazine-1-carboxylate
Type:
Small organic molecule
Emp. Form.:
C22H22N4O4S
Mol. Mass.:
438.499
SMILES:
CCOC(=O)N1CCN(CC1)C(=O)c1ccc(cc1)-n1c(=S)[nH]c2ccccc2c1=O
Structure:
Search PDB for entries with ligand similarity: