Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 3 [702-738,740-752]
Ligand
BDBM43527
Substrate
n/a
Meas. Tech.
Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors
IC50
>55690±n/a nM
Citation
 PubChem, PC Late stage counterscreen results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT3 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 3 [702-738,740-752]
Synonyms:
APRF | STAT3 | STAT3_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
5263.93
Organism:
Homo sapiens (Human)
Description:
gi_13272532
Residue:
50
Sequence:
AAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNGEGAEPSAGGQF
  
Inhibitor
Name:
BDBM43527
Synonyms:
2-[(7-hydroxy-2-keto-chromen-4-yl)methylthio]-1H-quinazolin-4-one | 2-[(7-hydroxy-2-oxo-1-benzopyran-4-yl)methylthio]-1H-quinazolin-4-one | 2-[(7-hydroxy-2-oxochromen-4-yl)methylsulfanyl]-1H-quinazolin-4-one | 2-[(7-oxidanyl-2-oxidanylidene-chromen-4-yl)methylsulfanyl]-1H-quinazolin-4-one | MLS000394219 | SMR000248604 | cid_5686694
Type:
Small organic molecule
Emp. Form.:
C18H12N2O4S
Mol. Mass.:
352.364
SMILES:
Oc1ccc2c(CSc3nc4ccccc4c(=O)[nH]3)cc(=O)oc2c1
Structure:
Search PDB for entries with ligand similarity: