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Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM67130
Substrate
n/a
Meas. Tech.
Late stage results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT1 inhibitors
IC50
>18562±n/a nM
Citation
 PubChem, PC Late stage results from the probe development effort to identify STAT1 inhibitors: luminescence-based cell-based dose response assay for STAT1 inhibitors PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM67130
Synonyms:
(2E)-2-[(4-methylpiperazino)methylene]-3-[[4-(4-sec-butylphenyl)thiazol-2-yl]methyl]-1H-quinazolin-4-one | (2E)-3-[[4-(4-butan-2-ylphenyl)-1,3-thiazol-2-yl]methyl]-2-[(4-methylpiperazin-1-yl)methylidene]-1H-quinazolin-4-one | (2E)-3-[[4-(4-butan-2-ylphenyl)-2-thiazolyl]methyl]-2-[(4-methyl-1-piperazinyl)methylidene]-1H-quinazolin-4-one | SR-03000000855-1 | cid_25181303
Type:
Small organic molecule
Emp. Form.:
C28H33N5OS
Mol. Mass.:
487.66
SMILES:
CCC(C)c1ccc(cc1)-c1csc(Cn2c(CN3CCN(C)CC3)nc3ccccc3c2=O)n1
Structure:
Search PDB for entries with ligand similarity: