Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM64703
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay
IC50
>40000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule antagonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM64703
Synonyms:
7-[(2-chlorophenyl)-(1-pyrrolidinyl)methyl]-8-quinolinol | 7-[(2-chlorophenyl)-pyrrolidin-1-yl-methyl]quinolin-8-ol | 7-[(2-chlorophenyl)-pyrrolidin-1-ylmethyl]quinolin-8-ol | 7-[(2-chlorophenyl)-pyrrolidino-methyl]quinolin-8-ol | MLS000761483 | SMR000371583 | cid_5187118
Type:
Small organic molecule
Emp. Form.:
C20H19ClN2O
Mol. Mass.:
338.831
SMILES:
Oc1c(ccc2cccnc12)C(N1CCCC1)c1ccccc1Cl
Structure:
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