Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM67998
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
7500±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM67998
Synonyms:
(E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(2-furanylmethylamino)-2-oxoethyl]-3-indolyl]-2-propenamide | (E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(2-furfurylamino)-2-keto-ethyl]indol-3-yl]acrylamide | (E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(furan-2-ylmethylamino)-2-oxidanylidene-ethyl]indol-3-yl]prop-2-enamide | (E)-2-cyano-N-(2,3-dimethylphenyl)-3-[1-[2-(furan-2-ylmethylamino)-2-oxoethyl]indol-3-yl]prop-2-enamide | 2-Cyano-N-(2,3-dimethyl-phenyl)-3-(1-{[(furan-2-ylmethyl)-carbamoyl]-methyl}-1H-indol-3-yl)-acrylamide | MLS000569213 | SMR000177748 | cid_1140634
Type:
Small organic molecule
Emp. Form.:
C27H24N4O3
Mol. Mass.:
452.5045
SMILES:
Cc1cccc(NC(=O)C(=C\c2cn(CC(=O)NCc3ccco3)c3ccccc23)\C#N)c1C
Structure:
Search PDB for entries with ligand similarity: