Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM68062
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
<160±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM68062
Synonyms:
MLS000335164 | N-cyclopropyl-5-[1-(2-fluorophenyl)-2,5-dimethyl-3-pyrrolyl]-6H-1,3,4-thiadiazin-2-amine | N-cyclopropyl-5-[1-(2-fluorophenyl)-2,5-dimethyl-pyrrol-3-yl]-6H-1,3,4-thiadiazin-2-amine | N-cyclopropyl-5-[1-(2-fluorophenyl)-2,5-dimethylpyrrol-3-yl]-6H-1,3,4-thiadiazin-2-amine | SMR000249922 | cid_4543045 | cyclopropyl-[5-[1-(2-fluorophenyl)-2,5-dimethyl-pyrrol-3-yl]-6H-1,3,4-thiadiazin-2-yl]amine
Type:
Small organic molecule
Emp. Form.:
C18H19FN4S
Mol. Mass.:
342.434
SMILES:
Cc1cc(c(C)n1-c1ccccc1F)C1=NN=C(NC2CC2)SC1 |t:16,18,(8.87,4.61,;7.96,3.37,;8.44,1.9,;7.19,1,;5.95,1.9,;4.48,1.43,;6.42,3.37,;5.52,4.61,;3.99,4.45,;3.08,5.7,;3.71,7.11,;5.24,7.27,;6.14,6.02,;7.67,6.18,;7.19,-.54,;8.53,-1.31,;8.53,-2.85,;7.19,-3.62,;7.19,-5.16,;8.53,-5.93,;9.3,-7.27,;10.07,-5.93,;5.86,-2.85,;5.86,-1.31,)|
Structure:
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