Reaction Details Report a problem with these data
Target
DNA damage-inducible transcript 3 protein
Ligand
BDBM57860
Substrate
n/a
Meas. Tech.
Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress
IC50
>10000±n/a nM
Citation
 PubChem, PC Dose-response primary assay and counterscreen assay for HTS small molecule inhibitors of CHOP to regulate the unfolded protein response to ER stress PubChem Bioassay (2010)[AID] 
Target
Name:
DNA damage-inducible transcript 3 protein
Synonyms:
Chop | Chop10 | DDIT3_MOUSE | Ddit3 | Gadd153
Type:
Enzyme Catalytic Domain
Mol. Mass.:
19175.17
Organism:
Mus musculus
Description:
gi_160707929
Residue:
168
Sequence:
MAAESLPFTLETVSSWELEAWYEDLQEVLSSDEIGGTYISSPGNEEEESKTFTTLDPASLAWLTEEPGPTEVTRTSQSPRSPDSSQSSMAQEEEEEEQGRTRKRKQSGQCPARPGKQRMKEKEQENERKVAQLAEENERLKQEIERLTREVETTRRALIDRMVSLHQA
  
Inhibitor
Name:
BDBM57860
Synonyms:
(2Z)-2-[(1-ethyl-8-methyl-2-quinolin-1-iumyl)methylidene]-3-methyl-1,3-benzothiazole;iodide | (2Z)-2-[(1-ethyl-8-methyl-quinolin-1-ium-2-yl)methylene]-3-methyl-1,3-benzothiazole;iodide | (2Z)-2-[(1-ethyl-8-methyl-quinolin-1-ium-2-yl)methylidene]-3-methyl-1,3-benzothiazole;iodide | (2Z)-2-[(1-ethyl-8-methylquinolin-1-ium-2-yl)methylidene]-3-methyl-1,3-benzothiazole;iodide | MLS000709676 | SMR000286543 | cid_16192857
Type:
Small organic molecule
Emp. Form.:
C21H21N2S
Mol. Mass.:
333.469
SMILES:
CC[n+]1c(\C=C2/Sc3ccccc3N2C)ccc2cccc(C)c12
Structure:
Search PDB for entries with ligand similarity: