Reaction Details Report a problem with these data
Target
UDP-galactopyranose mutase
Ligand
BDBM68247
Substrate
n/a
Meas. Tech.
High-throughput FP Assay
IC50
5.7e+3±n/a nM
Kd
1.6e+2± 5 nM
Citation
 Carlson, EE; May, JF; Kiessling, LL Chemical probes of UDP-galactopyranose mutase. Chem Biol 13:825-37 (2006) [PubMed]  Article 
Target
Name:
UDP-galactopyranose mutase
Synonyms:
GLF_MYCTU | UDP-galactopyranose mutase | Uridine 5'-diphosphate-galactopyranose mutase (UGM) | glf
Type:
Protein
Mol. Mass.:
45807.82
Organism:
Mycobacterium tuberculosis H37Rv
Description:
P9WIQ1
Residue:
399
Sequence:
MQPMTARFDLFVVGSGFFGLTIAERVATQLDKRVLVLERRPHIGGNAYSEAEPQTGIEVHKYGAHLFHTSNKRVWDYVRQFTDFTDYRHRVFAMHNGQAYQFPMGLGLVSQFFGKYFTPEQARQLIAEQAAEIDTADAQNLEEKAISLIGRPLYEAFVKGYTAKQWQTDPKELPAANITRLPVRYTFDNRYFSDTYEGLPTDGYTAWLQNMAADHRIEVRLNTDWFDVRGQLRPGSPAAPVVYTGPLDRYFDYAEGRLGWRTLDFEVEVLPIGDFQGTAVMNYNDLDVPYTRIHEFRHFHPERDYPTDKTVIMREYSRFAEDDDEPYYPINTEADRALLATYRARAKSETASSKVLFGGRLGTYQYLDMHMAIASALNMYDNVLAPHLRDGVPLLQDGA
  
Inhibitor
Name:
BDBM68247
Synonyms:
Fluorescent Probe 1
Type:
Small organic molecule
Emp. Form.:
C36H35N4O17P2S
Mol. Mass.:
889.694
SMILES:
OC1C(O)C(OC1COP([O-])(=O)OP([O-])(=O)OCCCCCCNC(=S)Nc1ccc(c(c1)C([O-])=O)-c1c2ccc(O)cc2oc2cc(=O)ccc12)n1ccc(=O)[nH]c1=O |(22.94,6.54,;24.09,7.57,;25.59,7.25,;26.22,5.84,;26.36,8.58,;25.33,9.73,;23.93,9.1,;22.59,9.87,;21.26,9.1,;19.93,9.87,;19.16,8.54,;20.7,11.21,;18.59,10.64,;17.26,9.87,;16.49,11.21,;18.03,8.54,;15.92,9.1,;14.59,9.87,;13.26,9.1,;11.92,9.87,;10.59,9.1,;9.26,9.87,;7.92,9.1,;6.59,9.87,;5.26,9.1,;5.26,7.56,;3.92,9.87,;2.59,9.1,;1.25,9.87,;-.08,9.1,;-.08,7.56,;1.25,6.79,;2.59,7.56,;1.25,5.25,;.63,3.85,;2.59,4.48,;-1.41,6.79,;-2.75,7.56,;-2.75,9.1,;-4.08,9.87,;-5.41,9.1,;-6.75,9.87,;-5.41,7.56,;-4.08,6.79,;-4.08,5.25,;-2.75,4.48,;-2.75,2.94,;-1.41,2.17,;-1.41,.63,;-.08,2.94,;-.08,4.48,;-1.41,5.25,;27.9,8.74,;28.8,7.5,;30.33,7.66,;30.96,9.07,;32.49,9.23,;30.05,10.31,;28.52,10.15,;27.62,11.4,)|
Structure:
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