Reaction Details Report a problem with these data
Target
Signal transducer and activator of transcription 1-alpha/beta
Ligand
BDBM43697
Substrate
n/a
Meas. Tech.
Late stage results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1)
EC50
2011±n/a nM
Citation
 PubChem, PC Late stage results from the probe development effort to identify activators of signal transducer and activator of transcription 1 (STAT1): luminescence-based cell-based dose response assay for STAT1 activators PubChem Bioassay (2010)[AID] 
Target
Name:
Signal transducer and activator of transcription 1-alpha/beta
Synonyms:
STAT1 | STAT1_HUMAN | Signal transducer and activator of transcription 1-alpha/beta | Transcription Factor STAT1 | Transcription factor ISGF-3 components p91/p84 | signal transducer and activator of transcription 1 isoform alpha
Type:
Cytosolic Transcription Factor
Mol. Mass.:
87327.69
Organism:
Homo sapiens (Human)
Description:
Stat1 was expressed in sf9 cells from a baculovirus encoding the recombinant proteins. Stat1 dimer binds to DNA.
Residue:
750
Sequence:
MSQWYELQQLDSKFLEQVHQLYDDSFPMEIRQYLAQWLEKQDWEHAANDVSFATIRFHDLLSQLDDQYSRFSLENNFLLQHNIRKSKRNLQDNFQEDPIQMSMIIYSCLKEERKILENAQRFNQAQSGNIQSTVMLDKQKELDSKVRNVKDKVMCIEHEIKSLEDLQDEYDFKCKTLQNREHETNGVAKSDQKQEQLLLKKMYLMLDNKRKEVVHKIIELLNVTELTQNALINDELVEWKRRQQSACIGGPPNACLDQLQNWFTIVAESLQQVRQQLKKLEELEQKYTYEHDPITKNKQVLWDRTFSLFQQLIQSSFVVERQPCMPTHPQRPLVLKTGVQFTVKLRLLVKLQELNYNLKVKVLFDKDVNERNTVKGFRKFNILGTHTKVMNMEESTNGSLAAEFRHLQLKEQKNAGTRTNEGPLIVTEELHSLSFETQLCQPGLVIDLETTSLPVVVISNVSQLPSGWASILWYNMLVAEPRNLSFFLTPPCARWAQLSEVLSWQFSSVTKRGLNVDQLNMLGEKLLGPNASPDGLIPWTRFCKENINDKNFPFWLWIESILELIKKHLLPLWNDGCIMGFISKERERALLKDQQPGTFLLRFSESSREGAITFTWVERSQNGGEPDFHAVEPYTKKELSAVTFPDIIRNYKVMAAENIPENPLKYLYPNIDKDHAFGKYYSRPKEAPEPMELDGPKGTGYIKTELISVSEVHPSRLQTTDNLLPMSPEEFDEVSRIVGSVEFDSMMNTV
  
Inhibitor
Name:
BDBM43697
Synonyms:
3-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-sulfanylidene-imidazolidin-4-one | 3-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-sulfanylideneimidazolidin-4-one | 3-[4-(4-methoxyphenyl)-1,3-thiazol-2-yl]-2-thioxo-4-imidazolidinone | 3-[4-(4-methoxyphenyl)-2-thiazolyl]-2-sulfanylidene-4-imidazolidinone | 3-[4-(4-methoxyphenyl)thiazol-2-yl]-2-thioxo-4-imidazolidinone | MLS000578852 | SMR000197838 | cid_898321
Type:
Small organic molecule
Emp. Form.:
C13H11N3O2S2
Mol. Mass.:
305.375
SMILES:
COc1ccc(cc1)-c1csc(n1)-n1c(O)c[nH]c1=S
Structure:
Search PDB for entries with ligand similarity: