Reaction Details Report a problem with these data
Target
ATP-dependent molecular chaperone HSP82
Ligand
BDBM64596
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole
EC50
<100±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay of Resistant C. albicans Growth in the Presence of Fluconazole PubChem Bioassay (2010)[AID] 
Target
Name:
ATP-dependent molecular chaperone HSP82
Synonyms:
heat shock protein 90
Type:
Enzyme Catalytic Domain
Mol. Mass.:
80784.12
Organism:
Candida albicans
Description:
gi_994798
Residue:
707
Sequence:
MADAKVETHEFTAEISQLMSLIINTVYSNKEIFLRELISNASDALDKIRYQALSDPSQLESEPELFIRIIPQKDQKVLEIRDSGIGMTKADLVNNLGTIAKSGTKSFMEALSAGADVSMIGQFGVGFYSLFLVADHVQVISKHNDDEQYVWESNAGGKFTVTLDETNERLGRGTMLRLFLKEDQLEYLEEKRIKEVVKKHSEFVAYPIQLVVTKEVEKEVPETEEEDKAAEEDDKKPKLEEVKDEEDEKKEKKTKTVKEEVTETEELNKTKPLWTRNPSDITQDEYNAFYKSISNDWEDPLAVKHFSVEGQLEFRAILFVPKRAPFDAFESKKKKNNIKLYVRRVFITDDAEELIPEWLSFIKGVVDSEDLPLNLSREMLQQNKILKVIRKNIVKKMIETFNEISEDQEQFNQFYTAFSKNIKLGIHEDAQNRQSLAKLLRFYSTKSSEEMTSLSDYVTRMPEHQKNIYYITGESIKAVEKSPFLDALKAKNFEVLFMVDPIDEYAMTQLKEFEDKKLVDITKDFELEESDEEKAAREKEIKEYEPLTKALKDILGDQVEKVVVSYKLVDAPAAIRTGQFGWSANMERIMKAQALRDTTMSSYMSSKKTFEISPSSPIIKELKKKVETDGAEDKTVKDLTTLLFDTALLTSGFTLDEPSNFAHRINRLIALGLNIDDDSEETAVEPEATTTASTDEPAGESAMEEVD
  
Inhibitor
Name:
BDBM64596
Synonyms:
7-Chloro-2-pyridin-3-yl-5-thiophen-2-yl-3H-benzo[e][1,2,4]triazepine | 7-chloranyl-2-pyridin-3-yl-5-thiophen-2-yl-4H-1,3,4-benzotriazepine | 7-chloro-2-(3-pyridinyl)-5-thiophen-2-yl-4H-1,3,4-benzotriazepine | 7-chloro-2-(3-pyridyl)-5-(2-thienyl)-4H-1,3,4-benzotriazepine | 7-chloro-2-pyridin-3-yl-5-thiophen-2-yl-4H-1,3,4-benzotriazepine | MLS000553261 | SMR000172707 | cid_855788
Type:
Small organic molecule
Emp. Form.:
C17H11ClN4S
Mol. Mass.:
338.814
SMILES:
Clc1ccc2=NC(=NNC(c3cccs3)=c2c1)c1cccnc1 |c:6,15,t:4|
Structure:
Search PDB for entries with ligand similarity: