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Target
Serine/threonine-protein phosphatase
Ligand
BDBM64558
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin
EC50
>285000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Based Secondary Assay to Identify Inhibitors of Calcineurin PubChem Bioassay (2010)[AID] 
Target
Name:
Serine/threonine-protein phosphatase
Synonyms:
calcineurin A1, putative | calmodulin-binding protein 1, putative | serine/threonine-protein phosphatase 2B catalytic subunit A1, putative
Type:
Enzyme Catalytic Domain
Mol. Mass.:
69558.03
Organism:
Candida dubliniensis CD36
Description:
gi_223640082
Residue:
607
Sequence:
MSGNTVQRNTEQINNALNAIQHRRTTTGNDLNHTNQRIISQNSINDKDYTIYITDDGEKYSTVERAVKSVDPPVTFKPKDEQVFLSNGKPNHQFLKQHFIHEGRLHEHQAIQILKQATHLLSKESNLLNVPAPVTICGDVHGQYYDLMKLFEVGGDPATTKYLFLGDYVDRGSFSIECLLYLYSLKINYPDTFWMLRGNHECRHLTEYFTFKNECLHKYSEQLYEECLVSFNALPLAAIMNEQFFCVHGGLSPQLTSLDSLRKLHRFREPPTKGLMCDLLWADPIEEYDEDNIDQEYVTNVVRGCSFAFTYKAACKFLDKTKLLSVIRAHEAQNAGYRMYKRTKTMGFPSLLTMFSAPNYLDSYNNKAAVLKYENNVMNIRQFNASPHPYWLPHFMDVFTWSLPFVGEKVTDMLVSILNVCTEEELDEDLPFSESEIGVATKTTKTTTPVSPVSPKAHPPSTRITSPYKSTKLVESDNNPNTNNDDSEMTLEEKKQALRNKIIAIGKMSRMFQVLREEQENVAHLKELNRGSLPKGSLLHGVDGLKNTINSFEEAKAADRINEALPPSPEDIQRLKQEKNTRIRQQIENQEMSGPVFQRLIRRLSQS
  
Inhibitor
Name:
BDBM64558
Synonyms:
(5,7-dichloroquinolin-8-yl) thiophene-2-carboxylate | 2-thiophenecarboxylic acid (5,7-dichloro-8-quinolinyl) ester | MLS000121674 | SMR000119051 | Thiophene-2-carboxylic acid 5,7-dichloro-quinolin-8-yl ester | [5,7-bis(chloranyl)quinolin-8-yl] thiophene-2-carboxylate | cid_700833 | thiophene-2-carboxylic acid (5,7-dichloro-8-quinolyl) ester
Type:
Small organic molecule
Emp. Form.:
C14H7Cl2NO2S
Mol. Mass.:
324.182
SMILES:
Clc1cc(Cl)c2cccnc2c1OC(=O)c1cccs1
Structure:
Search PDB for entries with ligand similarity: