Reaction Details Report a problem with these data
Target
Krueppel-like factor 5
Ligand
BDBM70217
Substrate
n/a
Meas. Tech.
Late stage results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): luminescence-based cell-based dose response assay for inhibitors of KLF5 (Round 1)
IC50
>39841±n/a nM
Citation
 PubChem, PC Late stage results from the probe development effort to identify inhibitors of kruppel-like factor 5 (KLF5): luminescence-based cell-based dose response assay for inhibitors of KLF5 (Round 1) PubChem Bioassay (2010)[AID] 
Target
Name:
Krueppel-like factor 5
Synonyms:
BTEB2 | CKLF | IKLF | KLF5 | KLF5_HUMAN | Kruppel-like factor 5
Type:
Enzyme Catalytic Domain
Mol. Mass.:
50808.71
Organism:
Homo sapiens (Human)
Description:
Q13887
Residue:
457
Sequence:
MATRVLSMSARLGPVPQPPAPQDEPVFAQLKPVLGAANPARDAALFPGEELKHAHHRPQAQPAPAQAPQPAQPPATGPRLPPEDLVQTRCEMEKYLTPQLPPVPIIPEHKKYRRDSASVVDQFFTDTEGLPYSINMNVFLPDITHLRTGLYKSQRPCVTHIKTEPVAIFSHQSETTAPPPAPTQALPEFTSIFSSHQTAAPEVNNIFIKQELPTPDLHLSVPTQQGHLYQLLNTPDLDMPSSTNQTAAMDTLNVSMSAAMAGLNTHTSAVPQTAVKQFQGMPPCTYTMPSQFLPQQATYFPPSPPSSEPGSPDRQAEMLQNLTPPPSYAATIASKLAIHNPNLPTTLPVNSQNIQPVRYNRRSNPDLEKRRIHYCDYPGCTKVYTKSSHLKAHLRTHTGEKPYKCTWEGCDWRFARSDELTRHYRKHTGAKPFQCGVCNRSFSRSDHLALHMKRHQN
  
Inhibitor
Name:
BDBM70217
Synonyms:
N-[5-(ethylcarbamoyl)-4-methyl-1,3-thiazol-2-yl]-1,3-benzothiazole-6-carboxamide | N-[5-(ethylcarbamoyl)-4-methyl-2-thiazolyl]-1,3-benzothiazole-6-carboxamide | N-[5-(ethylcarbamoyl)-4-methyl-thiazol-2-yl]-1,3-benzothiazole-6-carboxamide | SR-03000001334 | SR-03000001334-1 | cid_45259031
Type:
Small organic molecule
Emp. Form.:
C15H14N4O2S2
Mol. Mass.:
346.427
SMILES:
CCNC(=O)c1sc(NC(=O)c2ccc3ncsc3c2)nc1C
Structure:
Search PDB for entries with ligand similarity: