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Target
Kappa-type opioid receptor
Ligand
BDBM71608
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
IC50
5580±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule antagonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM71608
Synonyms:
4-(benzenesulfonamidomethyl)-N-[2-[(4-methoxyphenyl)methyl-propan-2-ylamino]ethyl]benzamide | 4-(benzenesulfonamidomethyl)-N-[2-[isopropyl(p-anisyl)amino]ethyl]benzamide | KSC-11-62-1 | KUC104500N | N-[2-[(4-methoxyphenyl)methyl-propan-2-yl-amino]ethyl]-4-(phenylsulfonylaminomethyl)benzamide | cid_44665684
Type:
Small organic molecule
Emp. Form.:
C27H33N3O4S
Mol. Mass.:
495.634
SMILES:
COc1ccc(CN(CCNC(=O)c2ccc(CNS(=O)(=O)c3ccccc3)cc2)C(C)C)cc1
Structure:
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