Reaction Details Report a problem with these data
Target
Heat shock factor protein 1
Ligand
BDBM72267
Substrate
n/a
Meas. Tech.
Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1)
EC50
8451±n/a nM
Citation
 PubChem, PC Luminescence Cell-Based Dose Retest to Identify Potentiators of Heat Shock Factor 1 (HSF1) PubChem Bioassay (2010)[AID] 
Target
Name:
Heat shock factor protein 1
Synonyms:
HSF1_MOUSE | Hsf1 | Hsf1 protein
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57208.68
Organism:
Mus musculus
Description:
P38532
Residue:
525
Sequence:
MDLAVGPGAAGPSNVPAFLTKLWTLVSDPDTDALICWSPSGNSFHVFDQGQFAKEVLPKYFKHNNMASFVRQLNMYGFRKVVHIEQGGLVKPERDDTEFQHPCFLRGQEQLLENIKRKVTSVSTLKSEDIKIRQDSVTRLLTDVQLMKGKQECMDSKLLAMKHENEALWREVASLRQKHAQQQKVVNKLIQFLISLVQSNRILGVKRKIPLMLSDSNSAHSVPKYGRQYSLEHVHGPGPYSAPSPAYSSSSLYSSDAVTSSGPIISDITELAPTSPLASPGRSIDERPLSSSTLVRVKQEPPSPPHSPRVLEASPGRPSSMDTPLSPTAFIDSILRESEPTPAASNTAPMDTTGAQAPALPTPSTPEKCLSVACLDKNELSDHLDAMDSNLDNLQTMLTSHGFSVDTSALLDLFSPSVTMPDMSLPDLDSSLASIQELLSPQEPPRPIEAENSNPDSGKQLVHYTAQPLFLLDPDAVDTGSSELPVLFELGESSYFSEGDDYTDDPTISLLTGTEPHKAKDPTVS
  
Inhibitor
Name:
BDBM72267
Synonyms:
1-(3-methylphenyl)-3-[(2-oxidanylideneindol-3-yl)amino]thiourea | 1-(3-methylphenyl)-3-[(2-oxo-3-indolyl)amino]thiourea | 1-(3-methylphenyl)-3-[(2-oxoindol-3-yl)amino]thiourea | 1-[(2-ketoindol-3-yl)amino]-3-(m-tolyl)thiourea | 1H-indole-2,3-dione 3-[N-(3-methylphenyl)thiosemicarbazone] | MLS000705089 | SMR000231438 | cid_5465946
Type:
Small organic molecule
Emp. Form.:
C16H14N4OS
Mol. Mass.:
310.374
SMILES:
Cc1cccc(NC(=S)NNC2=c3ccccc3=NC2=O)c1 |c:11,18|
Structure:
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