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Target
Eukaryotic translation initiation factor 4H
Ligand
BDBM73180
Substrate
n/a
Meas. Tech.
SAR analysis for the identification of translation initiation inhibitors (eIF4H)
IC50
10590±n/a nM
Citation
 PubChem, PC SAR analysis for the identification of translation initiation inhibitors (eIF4H) PubChem Bioassay (2010)[AID] 
Target
Name:
Eukaryotic translation initiation factor 4H
Synonyms:
EIF4H | IF4H_HUMAN | KIAA0038 | WBSCR1 | WSCR1
Type:
Enzyme Catalytic Domain
Mol. Mass.:
27385.24
Organism:
Homo sapiens (Human)
Description:
Q15056
Residue:
248
Sequence:
MADFDTYDDRAYSSFGGGRGSRGSAGGHGSRSQKELPTEPPYTAYVGNLPFNTVQGDIDAIFKDLSIRSVRLVRDKDTDKFKGFCYVEFDEVDSLKEALTYDGALLGDRSLRVDIAEGRKQDKGGFGFRKGGPDDRGMGSSRESRGGWDSRDDFNSGFRDDFLGGRGGSRPGDRRTGPPMGSRFRDGPPLRGSNMDFREPTEEERAQRPRLQLKPRTVATPLNQVANPNSAIFGGARPREEVVQKEQE
  
Inhibitor
Name:
BDBM73180
Synonyms:
3-[[2-[(E)-[2,5-diketo-1-[2-keto-2-(p-toluidino)ethyl]imidazolidin-4-ylidene]methyl]-6-methoxy-phenoxy]methyl]benzoic acid | 3-[[2-methoxy-6-[(E)-[1-[2-(4-methylanilino)-2-oxoethyl]-2,5-dioxo-4-imidazolidinylidene]methyl]phenoxy]methyl]benzoic acid | 3-[[2-methoxy-6-[(E)-[1-[2-(4-methylanilino)-2-oxoethyl]-2,5-dioxoimidazolidin-4-ylidene]methyl]phenoxy]methyl]benzoic acid | 3-[[2-methoxy-6-[(E)-[1-[2-[(4-methylphenyl)amino]-2-oxidanylidene-ethyl]-2,5-bis(oxidanylidene)imidazolidin-4-ylidene]methyl]phenoxy]methyl]benzoic acid | MLS-0355714.0001 | cid_24789851
Type:
Small organic molecule
Emp. Form.:
C28H25N3O7
Mol. Mass.:
515.514
SMILES:
COc1cccc(\C=C2\NC(=O)N(CC(=O)Nc3ccc(C)cc3)C2=O)c1OCc1cccc(c1)C(O)=O
Structure:
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