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Target
Importin subunit alpha-1
Ligand
BDBM74993
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74993
Synonyms:
MLS000728709 | N-[4-(2-thenoylamino)furazan-3-yl]thiophene-2-carboxamide | N-[4-(thiophen-2-ylcarbonylamino)-1,2,5-oxadiazol-3-yl]thiophene-2-carboxamide | N-[4-(thiophene-2-carbonylamino)-1,2,5-oxadiazol-3-yl]thiophene-2-carboxamide | N-[4-[[oxo(thiophen-2-yl)methyl]amino]-1,2,5-oxadiazol-3-yl]-2-thiophenecarboxamide | N-{4-[(thien-2-ylcarbonyl)amino]-1,2,5-oxadiazol-3-yl}thiophene-2-carboxamide | SMR000306988 | cid_573993
Type:
Small organic molecule
Emp. Form.:
C12H8N4O3S2
Mol. Mass.:
320.347
SMILES:
O=C(Nc1nonc1NC(=O)c1cccs1)c1cccs1
Structure:
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