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Target
Importin subunit alpha-1
Ligand
BDBM74996
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74996
Synonyms:
1-{[(2,6-dimethylphenyl)amino]carbonyl}-3-oxo-2-(thien-2-ylmethyl)-1,2,3,4-tetrahydropyrido[1,2-a]pyrazin-5-ium | MLS000731364 | N-(2,6-dimethylphenyl)-3-keto-2-(2-thenyl)-1,4-dihydropyrido[1,2-a]pyrazin-5-ium-1-carboxamide;iodide | N-(2,6-dimethylphenyl)-3-oxidanylidene-2-(thiophen-2-ylmethyl)-1,4-dihydropyrido[1,2-a]pyrazin-5-ium-1-carboxamide;iodide | N-(2,6-dimethylphenyl)-3-oxo-2-(thiophen-2-ylmethyl)-1,4-dihydropyrido[1,2-a]pyrazin-5-ium-1-carboxamide;iodide | SMR000309639 | cid_16193763
Type:
Small organic molecule
Emp. Form.:
C22H22N3O2S
Mol. Mass.:
392.493
SMILES:
Cc1cccc(C)c1NC(=O)C1N(Cc2cccs2)C(=O)C[n+]2ccccc12
Structure:
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