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Target
Importin subunit alpha-1
Ligand
BDBM74998
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM74998
Synonyms:
1-(5-bromanylthiophen-2-yl)sulfonyl-N-[2-(4-sulfamoylphenyl)ethyl]piperidine-4-carboxamide | 1-(5-bromothiophen-2-yl)sulfonyl-N-[2-(4-sulfamoylphenyl)ethyl]piperidine-4-carboxamide | 1-[(5-bromo-2-thienyl)sulfonyl]-N-[2-(4-sulfamoylphenyl)ethyl]isonipecotamide | 1-[(5-bromo-2-thiophenyl)sulfonyl]-N-[2-(4-sulfamoylphenyl)ethyl]-4-piperidinecarboxamide | MLS000675216 | N-{2-[4-(aminosulfonyl)phenyl]ethyl}-1-[(5-bromothien-2-yl)sulfonyl]piperidine-4-carboxamide | SMR000313938 | cid_16002642
Type:
Small organic molecule
Emp. Form.:
C18H22BrN3O5S3
Mol. Mass.:
536.483
SMILES:
NS(=O)(=O)c1ccc(CCNC(=O)C2CCN(CC2)S(=O)(=O)c2ccc(Br)s2)cc1
Structure:
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