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Target
Importin subunit alpha-1
Ligand
BDBM51188
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM51188
Synonyms:
(6E)-4-(2-chlorobenzyl)-6-[(3,4-dimethoxyanilino)methylene]-2-nitro-cyclohexa-2,4-dien-1-one | (6E)-4-[(2-chlorophenyl)methyl]-6-[(3,4-dimethoxyanilino)methylidene]-2-nitro-1-cyclohexa-2,4-dienone | (6E)-4-[(2-chlorophenyl)methyl]-6-[(3,4-dimethoxyanilino)methylidene]-2-nitrocyclohexa-2,4-dien-1-one | (6E)-4-[(2-chlorophenyl)methyl]-6-[[(3,4-dimethoxyphenyl)amino]methylidene]-2-nitro-cyclohexa-2,4-dien-1-one | 4-(2-chlorobenzyl)-2-{(E)-[(3,4-dimethoxyphenyl)imino]methyl}-6-nitrophenol | MLS000685578 | SMR000312542 | cid_16194520
Type:
Small organic molecule
Emp. Form.:
C22H19ClN2O5
Mol. Mass.:
426.85
SMILES:
COc1ccc(cc1OC)\[NH+]=C\c1c[c-](Cc2ccccc2Cl)cc([N+]([O-])=O)c1=O
Structure:
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