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Target
Importin subunit alpha-1
Ligand
BDBM75031
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
228100±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75031
Synonyms:
(3Z)-3-[(2,6-dimethylanilino)-hydroxy-methylene]-2,2-diketo-1-methyl-thieno[3,2-c]thiazin-4-one | (3Z)-3-[(2,6-dimethylanilino)-hydroxymethylidene]-1-methyl-2,2-dioxo-4-thieno[3,2-c]thiazinone | (3Z)-3-[(2,6-dimethylanilino)-hydroxymethylidene]-1-methyl-2,2-dioxothieno[3,2-c]thiazin-4-one | (3Z)-3-[[(2,6-dimethylphenyl)amino]-oxidanyl-methylidene]-1-methyl-2,2-bis(oxidanylidene)thieno[3,2-c][1,2]thiazin-4-one | MLS000755233 | N-(2,6-dimethylphenyl)-4-hydroxy-1-methyl-2,2-dioxo-1,2-dihydro-2lambda~6~-thieno[3,2-c][1,2]thiazine-3-carboxamide | SMR000338102 | cid_5523942
Type:
Small organic molecule
Emp. Form.:
C16H16N2O4S2
Mol. Mass.:
364.439
SMILES:
CN1c2ccsc2C(=O)C(C(=O)Nc2c(C)cccc2C)S1(=O)=O
Structure:
Search PDB for entries with ligand similarity: