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Target
Importin subunit alpha-1
Ligand
BDBM75074
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
40960±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75074
Synonyms:
(E)-3-(4-methylsulfanylphenyl)-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)sulfanyl]prop-2-enoic acid | (E)-3-[4-(methylthio)phenyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]-2-propenoic acid | (E)-3-[4-(methylthio)phenyl]-2-[(5-phenyl-1,3,4-oxadiazol-2-yl)thio]acrylic acid | MLS000759979 | SMR000370066 | cid_2496124
Type:
Small organic molecule
Emp. Form.:
C18H14N2O3S2
Mol. Mass.:
370.445
SMILES:
CSc1ccc(\C=C(\Sc2nnc(o2)-c2ccccc2)C(O)=O)cc1
Structure:
Search PDB for entries with ligand similarity: