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Target
Importin subunit alpha-1
Ligand
BDBM75075
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
54210±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75075
Synonyms:
MLS001004634 | N'-(1,3-dimethyl-2,4-dioxo-6-pteridinyl)-4-nitrobenzohydrazide | N'-(1,3-dimethyl-2,4-dioxopteridin-6-yl)-4-nitrobenzohydrazide | N'-(2,4-diketo-1,3-dimethyl-pteridin-6-yl)-4-nitro-benzohydrazide | N'-[1,3-dimethyl-2,4-bis(oxidanylidene)pteridin-6-yl]-4-nitro-benzohydrazide | SMR000348226 | cid_4199276
Type:
Small organic molecule
Emp. Form.:
C15H13N7O5
Mol. Mass.:
371.3076
SMILES:
Cn1c2ncc(NNC(=O)c3ccc(cc3)[N+]([O-])=O)nc2c(=O)n(C)c1=O
Structure:
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