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Target
Importin subunit alpha-1
Ligand
BDBM75076
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75076
Synonyms:
2-(3-pyridyl)-N-(2-thiazolin-2-yl)cinchoninamide;hydrochloride | MLS001005547 | N-(4,5-dihydro-1,3-thiazol-2-yl)-2-pyridin-3-yl-quinoline-4-carboxamide;hydrochloride | N-(4,5-dihydro-1,3-thiazol-2-yl)-2-pyridin-3-ylquinoline-4-carboxamide;hydrochloride | N-(4,5-dihydrothiazol-2-yl)-2-(3-pyridinyl)-4-quinolinecarboxamide;hydrochloride | SMR000348857 | cid_16196953
Type:
Small organic molecule
Emp. Form.:
C18H14N4OS
Mol. Mass.:
334.395
SMILES:
O=C(NC1=NCCS1)c1cc(nc2ccccc12)-c1cccnc1 |t:3|
Structure:
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