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Target
Importin subunit alpha-1
Ligand
BDBM75078
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
3735±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75078
Synonyms:
10-[3-(diisoamylamino)-2-hydroxy-propyl]acridin-9-one | 10-[3-[bis(3-methylbutyl)amino]-2-hydroxypropyl]-9-acridinone | 10-[3-[bis(3-methylbutyl)amino]-2-hydroxypropyl]acridin-9-one | 10-[3-[bis(3-methylbutyl)amino]-2-oxidanyl-propyl]acridin-9-one | 10-{3-[Bis-(3-methyl-butyl)-amino]-2-hydroxy-propyl}-10H-acridin-9-one | MLS001030199 | SMR000427298 | cid_3724486
Type:
Small organic molecule
Emp. Form.:
C26H36N2O2
Mol. Mass.:
408.5762
SMILES:
CC(C)CCN(CCC(C)C)CC(O)Cn1c2ccccc2c(=O)c2ccccc12
Structure:
Search PDB for entries with ligand similarity: