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Target
Importin subunit alpha-1
Ligand
BDBM75079
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75079
Synonyms:
(5E)-5-[(1-azepanylamino)methylidene]-1-(1-naphthalenyl)-1,3-diazinane-2,4,6-trione | (5E)-5-[(azepan-1-ylamino)methylene]-1-(1-naphthyl)barbituric acid | (5E)-5-[(azepan-1-ylamino)methylidene]-1-naphthalen-1-yl-1,3-diazinane-2,4,6-trione | 5-[1-(Azepan-1-ylamino)-meth-(E)-ylidene]-1-naphthalen-1-yl-pyrimidine-2,4,6-trione | MLS000332617 | SMR000435975 | cid_5620316
Type:
Small organic molecule
Emp. Form.:
C21H22N4O3
Mol. Mass.:
378.4244
SMILES:
Oc1c(C=NN2CCCCCC2)c(=O)[nH]c(=O)n1-c1cccc2ccccc12 |w:4.4,(7.72,1.65,;9.05,.88,;9.05,-.66,;7.72,-1.43,;7.72,-2.97,;6.39,-3.74,;5.11,-2.87,;3.64,-3.33,;3.08,-4.76,;3.85,-6.09,;5.37,-6.32,;6.5,-5.28,;10.39,-1.43,;10.39,-2.97,;11.72,-.66,;11.72,.88,;13.06,1.65,;10.39,1.65,;10.39,3.19,;9.05,3.96,;9.05,5.5,;10.39,6.27,;11.72,5.5,;13.1,6.32,;14.49,5.53,;14.49,3.93,;13.1,3.14,;11.72,3.96,)|
Structure:
Search PDB for entries with ligand similarity: