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Target
Importin subunit alpha-1
Ligand
BDBM75080
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
12450±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75080
Synonyms:
(Z)-4-(4-cyanophenyl)-2-keto-3-(2-quinolyl)but-3-enoic acid | (Z)-4-(4-cyanophenyl)-2-oxidanylidene-3-quinolin-2-yl-but-3-enoic acid | (Z)-4-(4-cyanophenyl)-2-oxo-3-(2-quinolinyl)-3-butenoic acid | (Z)-4-(4-cyanophenyl)-2-oxo-3-quinolin-2-ylbut-3-enoic acid | MLS001033775 | SMR000385650 | cid_6043656
Type:
Small organic molecule
Emp. Form.:
C20H12N2O3
Mol. Mass.:
328.3209
SMILES:
OC(=O)C(=O)C(=C/c1ccc(cc1)C#N)\c1ccc2ccccc2n1
Structure:
Search PDB for entries with ligand similarity: