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Target
Importin subunit alpha-1
Ligand
BDBM75082
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>260000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75082
Synonyms:
2-[[(E)-(6-keto-4-methyl-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-6-methyl-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester | 2-{[1-(2-Hydroxy-4-methyl-phenyl)-meth-(E)-ylidene]-amino}-6-methyl-4,5,6,7-tetrahydro-thieno[2,3-c]pyr idine-3-carboxylic acid ethyl ester | 6-methyl-2-[[(E)-(4-methyl-6-oxo-1-cyclohexa-2,4-dienylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylic acid ethyl ester | MLS000777153 | SMR000413549 | cid_6347707 | ethyl 6-methyl-2-[[(E)-(4-methyl-6-oxidanylidene-cyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate | ethyl 6-methyl-2-[[(E)-(4-methyl-6-oxocyclohexa-2,4-dien-1-ylidene)methyl]amino]-5,7-dihydro-4H-thieno[2,3-c]pyridine-3-carboxylate
Type:
Small organic molecule
Emp. Form.:
C19H22N2O3S
Mol. Mass.:
358.455
SMILES:
CCOC(=O)c1c2CCN(C)Cc2sc1N=Cc1ccc(C)cc1O |w:15.16|
Structure:
Search PDB for entries with ligand similarity: