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Target
Importin subunit alpha-1
Ligand
BDBM75096
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
6376±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM75096
Synonyms:
(E)-2-Cyano-3-(5-dimethylamino-furan-2-yl)-N-isopropyl-acrylamide | (E)-2-cyano-3-[5-(dimethylamino)-2-furanyl]-N-propan-2-yl-2-propenamide | (E)-2-cyano-3-[5-(dimethylamino)-2-furyl]-N-isopropyl-acrylamide | (E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-propan-2-yl-prop-2-enamide | (E)-2-cyano-3-[5-(dimethylamino)furan-2-yl]-N-propan-2-ylprop-2-enamide | MLS000333619 | SMR000437759 | cid_798423
Type:
Small organic molecule
Emp. Form.:
C13H17N3O2
Mol. Mass.:
247.293
SMILES:
CC(C)NC(=O)C(=C\c1ccc(o1)N(C)C)\C#N
Structure:
Search PDB for entries with ligand similarity: