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Target
Importin subunit alpha-1
Ligand
BDBM50693
Substrate
n/a
Meas. Tech.
Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex.
EC50
>500000±n/a nM
Citation
 PubChem, PC Fluorescence Cell-Free Homogeneous Counterscreen to Identify Inhibitors of the RanGTP-Importin-beta complex. PubChem Bioassay (2010)[AID] 
Target
Name:
Importin subunit alpha-1
Synonyms:
IMA1_HUMAN | KPNA2 | RCH1 | SRP1 | karyopherin alpha 2 (RAG cohort 1, importin alpha 1), isoform CRA_b
Type:
Enzyme Catalytic Domain
Mol. Mass.:
57852.15
Organism:
Homo sapiens (Human)
Description:
gi_119609447
Residue:
529
Sequence:
MSTNENANTPAARLHRFKNKGKDSTEMRRRRIEVNVELRKAKKDDQMLKRRNVSSFPDDATSPLQENRNNQGTVNWSVDDIVKGINSSNVENQLQATQAARKLLSREKQPPIDNIIRAGLIPKFVSFLGRTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFISLLASPHAHISEQAVWALGNIAGDGSVFRDLVIKYGAVDPLLALLAVPDMSSLACGYLRNLTWTLSNLCRNKNPAPPIDAVEQILPTLVRLLHHDDPEVLADTCWAISYLTDGPNERIGMVVKTGVVPQLVKLLGASELPIVTPALRAIGNIVTGTDEQTQVVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQIQQVVNHGLVPFLVSVLSKADFKTQKEAVWAVTNYTSGGTVEQIVYLVHCGIIEPLMNLLTAKDTKIILVILDAISNIFQAAEKLGETEKLSIMIEECGGLDKIEALQNHENESVYKASLSLIEKYFSVEEEEDQNVVPETTSEGYTFQVQDGAPGTFNF
  
Inhibitor
Name:
BDBM50693
Synonyms:
(5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylene)-2-thiazolin-4-one | (5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one | (5Z)-2-(4-fluoroanilino)-5-(1H-indol-3-ylmethylidene)-4-thiazolone | (5Z)-2-[(4-fluorophenyl)amino]-5-(1H-indol-3-ylmethylidene)-1,3-thiazol-4-one | 2-[(E)-4-Fluoro-phenylimino]-5-[1-(1H-indol-3-yl)-meth-(Z)-ylidene]-thiazolidin-4-one | MLS000806941 | SMR000414737 | cid_5530129
Type:
Small organic molecule
Emp. Form.:
C18H12FN3OS
Mol. Mass.:
337.371
SMILES:
Fc1ccc(NC2=NC(=O)C(S2)=Cc2c[nH]c3ccccc23)cc1 |w:12.13,t:6|
Structure:
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