Reaction Details Report a problem with these data
Target
Tyrosine-protein phosphatase non-receptor type 7
Ligand
BDBM75362
Substrate
n/a
Meas. Tech.
SAR analysis of compounds that inhibit HePTP - Set 2
IC50
100000±n/a nM
Citation
 PubChem, PC SAR analysis of compounds that inhibit HePTP - Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 7
Synonyms:
He-PTP | Hematopoietic protein-tyrosine phosphatase | Hematopoietic protein-tyrosine phosphatase (HEPTP) | PTN7_HUMAN | PTPN7 | Protein-tyrosine phosphatase LC-PTP | Tyrosine-protein phosphatase non-receptor type 7 | Tyrosine-protein phosphatase non-receptor type 7 (HEPTP)
Type:
Protein
Mol. Mass.:
40530.79
Organism:
Homo sapiens (Human)
Description:
P35236
Residue:
360
Sequence:
MVQAHGGRSRAQPLTLSLGAAMTQPPPEKTPAKKHVRLQERRGSNVALMLDVRSLGAVEPICSVNTPREVTLHFLRTAGHPLTRWALQRQPPSPKQLEEEFLKIPSNFVSPEDLDIPGHASKDRYKTILPNPQSRVCLGRAQSQEDGDYINANYIRGYDGKEKVYIATQGPMPNTVSDFWEMVWQEEVSLIVMLTQLREGKEKCVHYWPTEEETYGPFQIRIQDMKECPEYTVRQLTIQYQEERRSVKHILFSAWPDHQTPESAGPLLRLVAEVEESPETAAHPGPIVVHCSAGIGRTGCFIATRIGCQQLKARGEVDILGIVCQLRLDRGGMIQTAEQYQFLHHTLALYAGQLPEEPSP
  
Inhibitor
Name:
BDBM75362
Synonyms:
MLS-0435627.0001 | [4-amino-3-(4-methylphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone | [4-amino-3-(4-methylphenyl)-2-sulfanylidene-5-thiazolyl]-[4-(2-fluorophenyl)-1-piperazinyl]methanone | [4-amino-3-(p-tolyl)-2-thioxo-4-thiazolin-5-yl]-[4-(2-fluorophenyl)piperazino]methanone | [4-azanyl-3-(4-methylphenyl)-2-sulfanylidene-1,3-thiazol-5-yl]-[4-(2-fluorophenyl)piperazin-1-yl]methanone | cid_2385014
Type:
Small organic molecule
Emp. Form.:
C21H21FN4OS2
Mol. Mass.:
428.546
SMILES:
Cc1ccc(cc1)-n1c(N)c(sc1=S)C(=O)N1CCN(CC1)c1ccccc1F
Structure:
Search PDB for entries with ligand similarity: