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Target
Kappa-type opioid receptor
Ligand
BDBM75407
Substrate
n/a
Meas. Tech.
SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3
EC50
9250±n/a nM
Citation
 PubChem, PC SAR analysis of small molecule agonists of the kappa opioid receptor via a luminescent beta-arrestin assay - Set 3 PubChem Bioassay (2010)[AID] 
Target
Name:
Kappa-type opioid receptor
Synonyms:
K-OR-1 | KOR-1 | Kappa-opioid receptor (KOR) | Kappa-type opioid receptor (KOPR) | Kappa-type opioid receptor (KOR) | Kappa-type opioid receptor (Kappa) | OPIATE Kappa | OPRK | OPRK1 | OPRK_HUMAN | kappa opioid receptor (KOR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
42648.76
Organism:
Homo sapiens (Human)
Description:
P41145
Residue:
380
Sequence:
MDSPIQIFRGEPGPTCAPSACLPPNSSAWFPGWAEPDSNGSAGSEDAQLEPAHISPAIPVIITAVYSVVFVVGLVGNSLVMFVIIRYTKMKTATNIYIFNLALADALVTTTMPFQSTVYLMNSWPFGDVLCKIVISIDYYNMFTSIFTLTMMSVDRYIAVCHPVKALDFRTPLKAKIINICIWLLSSSVGISAIVLGGTKVREDVDVIECSLQFPDDDYSWWDLFMKICVFIFAFVIPVLIIIVCYTLMILRLKSVRLLSGSREKDRNLRRITRLVLVVVAVFVVCWTPIHIFILVEALGSTSHSTAALSSYYFCIALGYTNSSLNPILYAFLDENFKRCFRDFCFPLKMRMERQSTSRVRNTVQDPAYLRDIDGMNKPV
  
Inhibitor
Name:
BDBM75407
Synonyms:
KSC-10-30 | KUC104626N | N-[(6-methyl-2-oxidanylidene-1H-quinolin-3-yl)methyl]-N-(phenylmethyl)pyridine-2-carboxamide | N-[(6-methyl-2-oxo-1H-quinolin-3-yl)methyl]-N-(phenylmethyl)-2-pyridinecarboxamide | N-benzyl-N-[(2-keto-6-methyl-1H-quinolin-3-yl)methyl]picolinamide | N-benzyl-N-[(6-methyl-2-oxo-1H-quinolin-3-yl)methyl]pyridine-2-carboxamide | cid_44968281
Type:
Small organic molecule
Emp. Form.:
C24H21N3O2
Mol. Mass.:
383.4424
SMILES:
Cc1ccc2[nH]c(=O)c(CN(Cc3ccccc3)C(=O)c3ccccn3)cc2c1
Structure:
Search PDB for entries with ligand similarity: