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Target
Sphingosine 1-phosphate receptor 4
Ligand
BDBM75603
Substrate
n/a
Meas. Tech.
Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds
EC50
88.6±n/a nM
Citation
 PubChem, PC Late-stage fluorescence dose-response cell-based assay to identify agonists of the Sphingosine 1-Phosphate Receptor 4 (S1P4): Synthesized compounds PubChem Bioassay (2010)[AID] 
Target
Name:
Sphingosine 1-phosphate receptor 4
Synonyms:
EDG6 | Endothelial differentiation G-protein coupled receptor 6 | S1P receptor 4 | S1P receptor Edg-6 | S1P4 | S1PR4 | S1PR4_HUMAN | Sphingosine 1-phosphate receptor | Sphingosine 1-phosphate receptor Edg-6 | Sphingosine-1-phosphate receptor 4 | sphingosine-1-phosphate 4 S1P4
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
41647.39
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
384
Sequence:
MNATGTPVAPESCQQLAAGGHSRLIVLHYNHSGRLAGRGGPEDGGLGALRGLSVAASCLVVLENLLVLAAITSHMRSRRWVYYCLVNITLSDLLTGAAYLANVLLSGARTFRLAPAQWFLREGLLFTALAASTFSLLFTAGERFATMVRPVAESGATKTSRVYGFIGLCWLLAALLGMLPLLGWNCLCAFDRCSSLLPLYSKRYILFCLVIFAGVLATIMGLYGAIFRLVQASGQKAPRPAARRKARRLLKTVLMILLAFLVCWGPLFGLLLADVFGSNLWAQEYLRGMDWILALAVLNSAVNPIIYSFRSREVCRAVLSFLCCGCLRLGMRGPGDCLARAVEAHSGASTTDSSLRPRDSFRGSRSLSFRMREPLSSISSVRSI
  
Inhibitor
Name:
BDBM75603
Synonyms:
(5Z)-5-[[1-(2,6-difluorobenzyl)-2,5-dimethyl-pyrrol-3-yl]methylene]-3-methoxy-2-methylimino-thiazolidin-4-one | (5Z)-5-[[1-[(2,6-difluorophenyl)methyl]-2,5-dimethyl-3-pyrrolyl]methylidene]-3-methoxy-2-methylimino-4-thiazolidinone | (5Z)-5-[[1-[(2,6-difluorophenyl)methyl]-2,5-dimethylpyrrol-3-yl]methylidene]-3-methoxy-2-methylimino-1,3-thiazolidin-4-one | (5Z)-5-[[1-[[2,6-bis(fluoranyl)phenyl]methyl]-2,5-dimethyl-pyrrol-3-yl]methylidene]-3-methoxy-2-methylimino-1,3-thiazolidin-4-one | CYM50181 | SR-02000000305 | SR-02000000305-1 | cid_44620879
Type:
Small organic molecule
Emp. Form.:
C19H19F2N3O2S
Mol. Mass.:
391.435
SMILES:
CON1C(=O)\C(S\C1=N/C)=C\c1cc(C)n(Cc2c(F)cccc2F)c1C
Structure:
Search PDB for entries with ligand similarity: