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Target
Protein phosphatase methylesterase 1
Ligand
BDBM75707
Substrate
n/a
Meas. Tech.
Late stage assay provider results from the probe development effort to identify inhibitors of protein phosphatase methylesterase 1 (PME-1): Gel-based Activity-Based Protein Profiling (ABPP) IC50 Set 2
IC50
10±n/a nM
Citation
 PubChem, PC Late stage assay provider results from the probe development effort to identify inhibitors of protein phosphatase methylesterase 1 (PME-1): Gel-based Activity-Based Protein Profiling (ABPP) IC50 Set 2 PubChem Bioassay (2010)[AID] 
Target
Name:
Protein phosphatase methylesterase 1
Synonyms:
PME1 | PPME1 | PPME1_HUMAN
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42310.94
Organism:
Homo sapiens (Human)
Description:
gi_7706645
Residue:
386
Sequence:
MSALEKSMHLGRLPSRPPLPGSGGSQSGAKMRMGPGRKRDFSPVPWSQYFESMEDVEVENETGKDTFRVYKSGSEGPVLLLLHGGGHSALSWAVFTAAIISRVQCRIVALDLRSHGETKVKNPEDLSAETMAKDVGNVVEAMYGDLPPPIMLIGHSMGGAIAVHTASSNLVPSLLGLCMIDVVEGTAMDALNSMQNFLRGRPKTFKSLENAIEWSVKSGQIRNLESARVSMVGQVKQCEGITSPEGSKSIVEGIIEEEEEDEEGSESISKRKKEDDMETKKDHPYTWRIELAKTEKYWDGWFRGLSNLFLSCPIPKLLLLAGVDRLDKDLTIGQMQGKFQMQVLPQCGHAVHEDAPDKVAEAVATFLIRHRFAEPIGGFQCVFPGC
  
Inhibitor
Name:
BDBM75707
Synonyms:
(3R)-3-cyclopentyl-4-keto-3-phenyl-diazetidine-1,2-dicarboxylic acid dimethyl ester | (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylic acid dimethyl ester | ML174 | SR-01000786812 | SR-01000786812-5 | cid_24856225 | dimethyl (3R)-3-cyclopentyl-4-oxidanylidene-3-phenyl-1,2-diazetidine-1,2-dicarboxylate | dimethyl (3R)-3-cyclopentyl-4-oxo-3-phenyldiazetidine-1,2-dicarboxylate
Type:
Small organic molecule
Emp. Form.:
C17H20N2O5
Mol. Mass.:
332.3511
SMILES:
COC(=O)N1N(C(=O)OC)[C@@](C2CCCC2)(C1=O)c1ccccc1
Structure:
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