Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM75962
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
>4428±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM75962
Synonyms:
MLS000046585 | N-[3-(N-ethyl-3-methyl-anilino)propyl]-1-propylsulfonyl-isonipecotamide | N-[3-(N-ethyl-3-methylanilino)propyl]-1-propylsulfonyl-4-piperidinecarboxamide | N-[3-(N-ethyl-3-methylanilino)propyl]-1-propylsulfonylpiperidine-4-carboxamide | N-[3-[ethyl-(3-methylphenyl)amino]propyl]-1-propylsulfonyl-piperidine-4-carboxamide | N-{3-[ethyl(3-methylphenyl)amino]propyl}-1-(propylsulfonyl)piperidine-4-carboxamide | SMR000032596 | cid_3241674
Type:
Small organic molecule
Emp. Form.:
C21H35N3O3S
Mol. Mass.:
409.586
SMILES:
CCCS(=O)(=O)N1CCC(CC1)C(=O)NCCCN(CC)c1cccc(C)c1
Structure:
Search PDB for entries with ligand similarity: