Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM75969
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
3946±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM75969
Synonyms:
MLS000536380 | N-(3-chlorophenyl)-4-(3-methyl-4-oxidanylidene-phthalazin-1-yl)benzamide | N-(3-chlorophenyl)-4-(3-methyl-4-oxo-1-phthalazinyl)benzamide | N-(3-chlorophenyl)-4-(3-methyl-4-oxo-3,4-dihydro-1-phthalazinyl)benzamide | N-(3-chlorophenyl)-4-(3-methyl-4-oxophthalazin-1-yl)benzamide | N-(3-chlorophenyl)-4-(4-keto-3-methyl-phthalazin-1-yl)benzamide | SMR000143417 | cid_1292429
Type:
Small organic molecule
Emp. Form.:
C22H16ClN3O2
Mol. Mass.:
389.834
SMILES:
Cn1nc(-c2ccc(cc2)C(=O)Nc2cccc(Cl)c2)c2ccccc2c1=O
Structure:
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