Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM75982
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
4733±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM75982
Synonyms:
1-(1-azepanyl)-2-[(6-thiophen-2-yl-3-pyridazinyl)thio]ethanone | 1-(azepan-1-yl)-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanyl-ethanone | 1-(azepan-1-yl)-2-(6-thiophen-2-ylpyridazin-3-yl)sulfanylethanone | 1-(azepan-1-yl)-2-[[6-(2-thienyl)pyridazin-3-yl]thio]ethanone | MLS000696688 | SMR000237157 | cid_12006171
Type:
Small organic molecule
Emp. Form.:
C16H19N3OS2
Mol. Mass.:
333.472
SMILES:
O=C(CSc1ccc(nn1)-c1cccs1)N1CCCCCC1
Structure:
Search PDB for entries with ligand similarity: