Reaction Details Report a problem with these data
Target
Photoreceptor-specific nuclear receptor
Ligand
BDBM76022
Substrate
n/a
Meas. Tech.
TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists
IC50
3383±n/a nM
Citation
 PubChem, PC TR-FRET-based biochemical high throughput dose response assay to identify NR2E3 inverse agonists PubChem Bioassay (2010)[AID] 
Target
Name:
Photoreceptor-specific nuclear receptor
Synonyms:
NR2E3 | NR2E3_HUMAN | PNR | RNR | photoreceptor-specific nuclear receptor
Type:
PROTEIN
Mol. Mass.:
44699.83
Organism:
Homo sapiens (Human)
Description:
ChEMBL_401901
Residue:
410
Sequence:
METRPTALMSSTVAAAAPAAGAASRKESPGRWGLGEDPTGVSPSLQCRVCGDSSSGKHYGIYACNGCSGFFKRSVRRRLIYRCQVGAGMCPVDKAHRNQCQACRLKKCLQAGMNQDAVQNERQPRSTAQVHLDSMESNTESRPESLVAPPAPAGRSPRGPTPMSAARALGHHFMASLITAETCAKLEPEDADENIDVTSNDPEFPSSPYSSSSPCGLDSIHETSARLLFMAVKWAKNLPVFSSLPFRDQVILLEEAWSELFLLGAIQWSLPLDSCPLLAPPEASAAGGAQGRLTLASMETRVLQETISRFRALAVDPTEFACMKALVLFKPETRGLKDPEHVEALQDQSQVMLSQHSKAHHPSQPVRFGKLLLLLPSLRFITAERIELLFFRKTIGNTPMEKLLCDMFKN
  
Inhibitor
Name:
BDBM76022
Synonyms:
5-bromanyl-N-[4-(6-methoxypyridazin-3-yl)phenyl]furan-2-carboxamide | 5-bromo-N-[4-(6-methoxy-3-pyridazinyl)phenyl]-2-furancarboxamide | 5-bromo-N-[4-(6-methoxypyridazin-3-yl)phenyl]-2-furamide | 5-bromo-N-[4-(6-methoxypyridazin-3-yl)phenyl]furan-2-carboxamide | MLS001236653 | SMR000812782 | cid_7593595
Type:
Small organic molecule
Emp. Form.:
C16H12BrN3O3
Mol. Mass.:
374.189
SMILES:
COc1ccc(nn1)-c1ccc(NC(=O)c2ccc(Br)o2)cc1
Structure:
Search PDB for entries with ligand similarity: