Reaction Details Report a problem with these data
Target
Apelin receptor
Ligand
BDBM76104
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay
EC50
>100000±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule agonists of the APJ receptor via a luminescent beta-arrestin assay PubChem Bioassay (2010)[AID] 
Target
Name:
Apelin receptor
Synonyms:
AGTRL1 | APJ | APJ_HUMAN | APLNR | Angiotensin receptor-like 1 | Apelin receptor | Apelin receptor (APJ) | G-protein coupled receptor APJ | G-protein coupled receptor HG11
Type:
Enzyme Catalytic Domain
Mol. Mass.:
42664.06
Organism:
Homo sapiens (Human)
Description:
P35414
Residue:
380
Sequence:
MEEGGDFDNYYGADNQSECEYTDWKSSGALIPAIYMLVFLLGTTGNGLVLWTVFRSSREKRRSADIFIASLAVADLTFVVTLPLWATYTYRDYDWPFGTFFCKLSSYLIFVNMYASVFCLTGLSFDRYLAIVRPVANARLRLRVSGAVATAVLWVLAALLAMPVMVLRTTGDLENTTKVQCYMDYSMVATVSSEWAWEVGLGVSSTTVGFVVPFTIMLTCYFFIAQTIAGHFRKERIEGLRKRRRLLSIIVVLVVTFALCWMPYHLVKTLYMLGSLLHWPCDFDLFLMNIFPYCTCISYVNSCLNPFLYAFFDPRFRQACTSMLCCGQSRCAGTSHSSSGEKSASYSSGHSQGPGPNMGKGGEQMHEKSIPYSQETLVVD
  
Inhibitor
Name:
BDBM76104
Synonyms:
6,7-diethoxy-3-[(1-ethyl-2-pyrrolidinyl)methyl]-2-sulfanylidene-1H-quinazolin-4-one | 6,7-diethoxy-3-[(1-ethylpyrrolidin-2-yl)methyl]-2-sulfanylidene-1H-quinazolin-4-one | 6,7-diethoxy-3-[(1-ethylpyrrolidin-2-yl)methyl]-2-thioxo-1H-quinazolin-4-one | 6,7-diethoxy-3-[(1-ethylpyrrolidin-2-yl)methyl]-2-thioxo-2,3-dihydroquinazolin-4(1H)-one | MLS000095444 | SMR000030998 | cid_3244277
Type:
Small organic molecule
Emp. Form.:
C19H27N3O3S
Mol. Mass.:
377.501
SMILES:
CCOc1cc2[nH]c(=S)n(CC3CCCN3CC)c(=O)c2cc1OCC
Structure:
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