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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM46229
Substrate
n/a
Meas. Tech.
Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay
EC50
5570±n/a nM
Citation
 PubChem, PC Dose Response concentration confirmation of uHTS hits from a small molecule activators of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM46229
Synonyms:
4-chloranyl-N-(3,4-dihydro-2H-thiochromen-4-yl)-3-sulfamoyl-benzamide | 4-chloro-3-sulfamoyl-N-thiochroman-4-yl-benzamide | 4-chloro-N-(3,4-dihydro-2H-1-benzothiopyran-4-yl)-3-sulfamoylbenzamide | 4-chloro-N-(3,4-dihydro-2H-thiochromen-4-yl)-3-sulfamoylbenzamide | MLS-0336143.0001 | cid_16330874
Type:
Small organic molecule
Emp. Form.:
C16H15ClN2O3S2
Mol. Mass.:
382.885
SMILES:
NS(=O)(=O)c1cc(ccc1Cl)C(=O)NC1CCSc2ccccc12
Structure:
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