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Target
Intestinal-type alkaline phosphatase 1
Ligand
BDBM76207
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay
IC50
485±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS hits from a small molecule inhibitors of mouse intestinal alkaline phosphatase via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Intestinal-type alkaline phosphatase 1
Synonyms:
Alpi | PPBI1_RAT
Type:
Enzyme Catalytic Domain
Mol. Mass.:
58396.39
Organism:
Rattus norvegicus (Rat)
Description:
P15693
Residue:
540
Sequence:
MQGDWVLLLLLGLRIHLSFGVIPVEEENPVFWNQKAKEALDVAKKLQPIQTSAKNLILFLGDGMGVPTVTATRILKGQLGGHLGPETPLAMDHFPFTALSKTYNVDRQVPDSAGTATAYLCGVKANYKTIGVSAAARFNQCNSTFGNEVFSVMHRAKKAGKSVGVVTTTRVQHASPAGTYAHTVNRDWYSDADMPSSALQEGCKDIATQLISNMDIDVILGGGRKFMFPKGTPDPEYPGDSDQSGVRLDSRNLVEEWLAKYQGTRYVWNREQLMQASQDPAVTRLMGLFEPTEMKYDVNRNASADPSLAEMTEVAVRLLSRNPQGFYLFVEGGRIDQGHHAGTAYLALTEAVMFDSAIEKASQLTNEKDTLTLITADHSHVFAFGGYTLRGTSIFGLAPLNAQDGKSYTSILYGNGPGYVLNSGNRPNVTDAESGDVNYKQQAAVPLSSETHGGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAGCLEPYTDCGLAPPADENRPTTPVQNSAITMNNVLLSLQLLVSMLLLVGTALVVS
  
Inhibitor
Name:
BDBM76207
Synonyms:
2-(3-Cyano-7-hydroxy-5-oxo-4,5-dihydro-thieno[3,2-b]pyridin-2-ylsulfanyl)-N-thiazol-2-yl-acetamide | 2-[(3-cyano-5-hydroxy-7-keto-4H-thieno[3,2-b]pyridin-2-yl)thio]-N-thiazol-2-yl-acetamide | 2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[3,2-b]pyridin-2-yl)sulfanyl]-N-(1,3-thiazol-2-yl)acetamide | 2-[(3-cyano-5-hydroxy-7-oxo-4H-thieno[3,2-b]pyridin-2-yl)thio]-N-(2-thiazolyl)acetamide | 2-[(3-cyano-5-oxidanyl-7-oxidanylidene-4H-thieno[3,2-b]pyridin-2-yl)sulfanyl]-N-(1,3-thiazol-2-yl)ethanamide | 2-[(3-cyano-7-hydroxy-5-keto-4H-thieno[3,2-b]pyridin-2-yl)thio]-N-thiazol-2-yl-acetamide | MLS001222104 | SMR000606646 | cid_54691675 | cid_6499471
Type:
Small organic molecule
Emp. Form.:
C13H8N4O3S3
Mol. Mass.:
364.423
SMILES:
Oc1cc(=O)[nH]c2c(C#N)c(SCC(=O)Nc3nccs3)sc12
Structure:
Search PDB for entries with ligand similarity: