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Target
Alkaline phosphatase, tissue-nonspecific isozyme
Ligand
BDBM76189
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase.
IC50
11800±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS inhibitors of Mouse Intestinal Alkaline Phosphatase using Tissue Nonspecific Alkaline Phosphatase. PubChem Bioassay (2010)[AID] 
Target
Name:
Alkaline phosphatase, tissue-nonspecific isozyme
Synonyms:
ALPL | PPBT_HUMAN | tissue-nonspecific alkaline phosphatase precursor
Type:
PROTEIN
Mol. Mass.:
57306.17
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1448917
Residue:
524
Sequence:
MISPFLVLAIGTCLTNSLVPEKEKDPKYWRDQAQETLKYALELQKLNTNVAKNVIMFLGDGMGVSTVTAARILKGQLHHNPGEETRLEMDKFPFVALSKTYNTNAQVPDSAGTATAYLCGVKANEGTVGVSAATERSRCNTTQGNEVTSILRWAKDAGKSVGIVTTTRVNHATPSAAYAHSADRDWYSDNEMPPEALSQGCKDIAYQLMHNIRDIDVIMGGGRKYMYPKNKTDVEYESDEKARGTRLDGLDLVDTWKSFKPRYKHSHFIWNRTELLTLDPHNVDYLLGLFEPGDMQYELNRNNVTDPSLSEMVVVAIQILRKNPKGFFLLVEGGRIDHGHHEGKAKQALHEAVEMDRAIGQAGSLTSSEDTLTVVTADHSHVFTFGGYTPRGNSIFGLAPMLSDTDKKPFTAILYGNGPGYKVVGGERENVSMVDYAHNNYQAQSAVPLRHETHGGEDVAVFSKGPMAHLLHGVHEQNYVPHVMAYAACIGANLGHCAPASSAGSLAAGPLLLALALYPLSVLF
  
Inhibitor
Name:
BDBM76189
Synonyms:
(5-chloranyl-2-oxidanylidene-1,3-benzoxathiol-6-yl) N-cyclohexylcarbamate | (5-chloro-2-oxo-1,3-benzoxathiol-6-yl) N-cyclohexylcarbamate | 5-chloro-2-oxo-1,3-benzoxathiol-6-yl cyclohexylcarbamate | MLS000766725 | N-cyclohexylcarbamic acid (5-chloro-2-keto-1,3-benzoxathiol-6-yl) ester | N-cyclohexylcarbamic acid (5-chloro-2-oxo-1,3-benzoxathiol-6-yl) ester | SMR000339621 | cid_691373
Type:
Small organic molecule
Emp. Form.:
C14H14ClNO4S
Mol. Mass.:
327.783
SMILES:
Clc1cc2sc(=O)oc2cc1OC(=O)NC1CCCCC1
Structure:
Search PDB for entries with ligand similarity: