Reaction Details Report a problem with these data
Target
RecBCD enzyme subunit RecD
Ligand
BDBM59533
Substrate
n/a
Meas. Tech.
Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD
IC50
56351±n/a nM
Citation
 PubChem, PC Counterscreen for AddAB inhibitors: absorbance-based bacterial cell-based high throughput dose response assay to identify inhibitors of RecBCD PubChem Bioassay (2010)[AID] 
Target
Name:
RecBCD enzyme subunit RecD
Synonyms:
RECD_ECOLI | exonuclease V (RecBCD complex), alpha chain | hopE | recD
Type:
Enzyme Catalytic Domain
Mol. Mass.:
66906.68
Organism:
Escherichia coli str. K-12 substr. MG1655
Description:
gi_16130723
Residue:
608
Sequence:
MKLQKQLLEAVEHKQLRPLDVQFALTVAGDEHPAVTLAAALLSHDAGEGHVCLPLSRLENNEASHPLLATCVSEIGELQNWEECLLASQAVSRGDEPTPMILCGDRLYLNRMWCNERTVARFFNEVNHAIEVDEALLAQTLDKLFPVSDEINWQKVAAAVALTRRISVISGGPGTGKTTTVAKLLAALIQMADGERCRIRLAAPTGKAAARLTESLGKALRQLPLTDEQKKRIPEDASTLHRLLGAQPGSQRLRHHAGNPLHLDVLVVDEASMIDLPMMSRLIDALPDHARVIFLGDRDQLASVEAGAVLGDICAYANAGFTAERARQLSRLTGTHVPAGTGTEAASLRDSLCLLQKSYRFGSDSGIGQLAAAINRGDKTAVKTVFQQDFTDIEKRLLQSGEDYIAMLEEALAGYGRYLDLLQARAEPDLIIQAFNEYQLLCALREGPFGVAGLNERIEQFMQQKRKIHRHPHSRWYEGRPVMIARNDSALGLFNGDIGIALDRGQGTRVWFAMPDGNIKSVQPSRLPEHETTWAMTVHKSQGSEFDHAALILPSQRTPVVTRELVYTAVTRARRRLSLYADERILSAAIATRTERRSGLAALFSSRE
  
Inhibitor
Name:
BDBM59533
Synonyms:
4-amino-N'-[(1E)-(5-nitro-2-furyl)methylene]-1,2,5-oxadiazole-3-carbohydrazide | 4-amino-N-[(5-nitro-2-furanyl)methylideneamino]-1,2,5-oxadiazole-3-carboxamide | 4-amino-N-[(5-nitro-2-furyl)methyleneamino]furazan-3-carboxamide | 4-amino-N-[(5-nitrofuran-2-yl)methylideneamino]-1,2,5-oxadiazole-3-carboxamide | 4-azanyl-N-[(5-nitrofuran-2-yl)methylideneamino]-1,2,5-oxadiazole-3-carboxamide | MLS000720034 | SMR000304563 | cid_3747686
Type:
Small organic molecule
Emp. Form.:
C8H6N6O5
Mol. Mass.:
266.1704
SMILES:
Nc1nonc1C(=O)N\N=C\c1ccc(o1)[N+]([O-])=O
Structure:
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