Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM10
Ligand
BDBM78191
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay
IC50
30300±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1 yeast via a luminescent assay PubChem Bioassay (2010)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM10
Synonyms:
MRS11 | TIM10 | TIM10_YEAST | TPA: Essential protein of the mitochondrial intermembrane space | TPA: Essential protein of the mitochondrial intermembrane space, forms a complex with Tim9p (TIM10 complex) that delivers hydrophobic proteins to the TIM22 complex for insertion into the inner ...
Type:
Enzyme Catalytic Domain
Mol. Mass.:
10303.50
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285809906
Residue:
93
Sequence:
MSFLGFGGGQPQLSSQQKIQAAEAELDLVTDMFNKLVNNCYKKCINTSYSEGELNKNESSCLDRCVAKYFETNVQVGENMQKMGQSFNAAGKF
  
Inhibitor
Name:
BDBM78191
Synonyms:
4-Methyl-furazan-3-carboxylic acid (4-hydroxy-benzylidene)-hydrazide | 4-methyl-N'-[(4-oxidanylidenecyclohexa-2,5-dien-1-ylidene)methyl]-1,2,5-oxadiazole-3-carbohydrazide | 4-methyl-N'-[(4-oxo-1-cyclohexa-2,5-dienylidene)methyl]-1,2,5-oxadiazole-3-carbohydrazide | 4-methyl-N'-[(4-oxocyclohexa-2,5-dien-1-ylidene)methyl]-1,2,5-oxadiazole-3-carbohydrazide | MLS000547777 | N'-[(4-ketocyclohexa-2,5-dien-1-ylidene)methyl]-4-methyl-furazan-3-carbohydrazide | SMR000171280 | cid_5406001
Type:
Small organic molecule
Emp. Form.:
C11H10N4O3
Mol. Mass.:
246.2221
SMILES:
Cc1nonc1C(=O)NN=Cc1ccc(O)cc1 |w:9.9|
Structure:
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