Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78182
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
1380±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78182
Synonyms:
2-(3,4-dichlorophenyl)-N'-[(3,4-dimethoxybenzoyl)oxy]ethanimidamide | 3,4-dimethoxybenzoic acid [(Z)-[1-amino-2-(3,4-dichlorophenyl)ethylidene]amino] ester | MLS000578928 | SMR000198749 | [(Z)-[1-amino-2-(3,4-dichlorophenyl)ethylidene]amino] 3,4-dimethoxybenzoate | [(Z)-[1-azanyl-2-(3,4-dichlorophenyl)ethylidene]amino] 3,4-dimethoxybenzoate | cid_9587530
Type:
Small organic molecule
Emp. Form.:
C17H16Cl2N2O4
Mol. Mass.:
383.226
SMILES:
COc1ccc(cc1OC)C(=O)ON=C(N)Cc1ccc(Cl)c(Cl)c1 |w:13.13|
Structure:
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