Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM78265
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
3130±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM78265
Synonyms:
2-({1-[3-(methoxycarbonyl)-4,5,6,7-tetrahydro-1-benzothien-2-yl]-2,5-dioxo-3-pyrrolidinyl}thio)benzoic acid | 2-[1-(3-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2,5-bis(oxidanylidene)pyrrolidin-3-yl]sulfanylbenzoic acid | 2-[1-(3-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2,5-dioxopyrrolidin-3-yl]sulfanylbenzoic acid | 2-[[1-(3-carbomethoxy-4,5,6,7-tetrahydrobenzothiophen-2-yl)-2,5-diketo-pyrrolidin-3-yl]thio]benzoic acid | 2-[[1-(3-methoxycarbonyl-4,5,6,7-tetrahydro-1-benzothiophen-2-yl)-2,5-dioxo-3-pyrrolidinyl]thio]benzoic acid | MLS000676551 | SMR000298619 | cid_2906471
Type:
Small organic molecule
Emp. Form.:
C21H19NO6S2
Mol. Mass.:
445.509
SMILES:
COC(=O)c1c2CCCCc2sc1-n1c(O)cc(Sc2ccccc2C(O)=O)c1O |(7.13,5.33,;6.65,3.86,;7.68,2.72,;9.19,3.03,;7.2,1.25,;5.75,.78,;4.41,1.55,;3.08,.78,;3.08,-.76,;4.41,-1.53,;5.75,-.76,;7.2,-1.23,;8.1,.01,;9.64,.01,;10.55,1.26,;10.07,2.72,;12.01,.78,;12.01,-.76,;13.26,-1.66,;14.67,-1.04,;14.83,.5,;16.23,1.12,;17.48,.22,;17.32,-1.31,;15.91,-1.94,;15.75,-3.47,;17,-4.38,;14.34,-4.1,;10.55,-1.23,;10.07,-2.7,)|
Structure:
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