Reaction Details Report a problem with these data
Target
Mitochondrial import inner membrane translocase subunit TIM23
Ligand
BDBM60974
Substrate
n/a
Meas. Tech.
Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen.
IC50
2520±n/a nM
Citation
 PubChem, PC Dose Response confirmation of uHTS small molecule inhibitors of tim10-1: a luminescent tim23-1 yeast counterscreen. PubChem Bioassay (2011)[AID] 
Target
Name:
Mitochondrial import inner membrane translocase subunit TIM23
Synonyms:
MAS6 | MIM23 | MPI3 | TIM23 | TIM23_YEAST | TPA: Essential component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex)
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23245.32
Organism:
Saccharomyces cerevisiae S288c
Description:
gi_285814664
Residue:
222
Sequence:
MSWLFGDKTPTDDANAAVGGQDTTKPKELSLKQSLGFEPNINNIISGPGGMHVDTARLHPLAGLDKGVEYLDLEEEQLSSLEGSQGLIPSRGWTDDLCYGTGAVYLLGLGIGGFSGMMQGLQNIPPNSPGKLQLNTVLNHITKRGPFLGNNAGILALSYNIINSTIDALRGKHDTAGSIGAGALTGALFKSSKGLKPMGYSSAMVAAACAVWCSVKKRLLEK
  
Inhibitor
Name:
BDBM60974
Synonyms:
MLS001291206 | N-(3-maleimidophenyl)thiophene-2-carboxamide | N-[3-(2,5-dioxo-1-pyrrolyl)phenyl]-2-thiophenecarboxamide | N-[3-(2,5-dioxopyrrol-1-yl)phenyl]thiophene-2-carboxamide | N-[3-[2,5-bis(oxidanylidene)pyrrol-1-yl]phenyl]thiophene-2-carboxamide | SMR000611660 | Thiophene-2-carboxylic acid [3-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-phenyl]-amide | cid_881135
Type:
Small organic molecule
Emp. Form.:
C15H10N2O3S
Mol. Mass.:
298.316
SMILES:
O=C(Nc1cccc(c1)N1C(=O)C=CC1=O)c1cccs1 |c:13|
Structure:
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