Reaction Details Report a problem with these data
Target
Tropomyosin alpha-1 chain
Ligand
BDBM40036
Substrate
n/a
Meas. Tech.
Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF)
EC50
11632±n/a nM
Citation
 PubChem, PC Fluorescence-based biochemical high throughput dose response assay for activators of the calcium sensitivity of cardiac Regulated Thin Filaments (RTF) PubChem Bioassay (2011)[AID] 
Target
Name:
Tropomyosin alpha-1 chain
Synonyms:
TPM1 | TPM1_PIG | cardiac alpha tropomyosin
Type:
Enzyme Catalytic Domain
Mol. Mass.:
32681.01
Organism:
Sus scrofa
Description:
P42639
Residue:
284
Sequence:
MDAIKKKMQMLKLDKENALDRAEQAEADKKAAEDRSKRLEDELVSLQKKLKATEDELDKYSEAPKDAQEKLELAEKKATDAEADVASLNRRIQLVEEELDRAQERLATALQKLEEAEKAADESERGMKVIESRAQKDEEKMEIQEIQLKEAKHIAEDADRKYEEVARKLVIIESDLERAEERAELSEGKCAELEEELKTVTNNLKSLEAQAEKYSQKEDKYEEEIKVLSDKLKEAETRAEFAERSVTKLEKSIDDLEDELYAQKLKYKAISEELDHALNDMTSI
  
Inhibitor
Name:
BDBM40036
Synonyms:
MLS000094596 | N-[4-({(E)-[2-(4-methylphenyl)-5-oxo-1,3-oxazol-4(5H)-ylidene]methyl}amino)phenyl]acetamide | N-[4-[[(Z)-[2-(4-methylphenyl)-5-oxidanylidene-1,3-oxazol-4-ylidene]methyl]amino]phenyl]ethanamide | N-[4-[[(Z)-[2-(4-methylphenyl)-5-oxo-1,3-oxazol-4-ylidene]methyl]amino]phenyl]acetamide | N-[4-[[(Z)-[2-(4-methylphenyl)-5-oxo-4-oxazolylidene]methyl]amino]phenyl]acetamide | N-[4-[[(Z)-[5-keto-2-(p-tolyl)-2-oxazolin-4-ylidene]methyl]amino]phenyl]acetamide | SMR000030149 | cid_5771420
Type:
Small organic molecule
Emp. Form.:
C19H17N3O3
Mol. Mass.:
335.3566
SMILES:
CC(=O)Nc1ccc(cc1)N=Cc1nc(oc1O)-c1ccc(C)cc1 |w:10.10|
Structure:
Search PDB for entries with ligand similarity: