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Target
Orexin/Hypocretin receptor type 1
Ligand
BDBM79864
Substrate
n/a
Meas. Tech.
Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1)
IC50
>5527±n/a nM
Citation
 PubChem, PC Fluorescence-based cell-based high throughput dose response assay for antagonists of the orexin 1 receptor (OX1R; HCRTR1) PubChem Bioassay (2011)[AID] 
Target
Name:
Orexin/Hypocretin receptor type 1
Synonyms:
HCRTR1 | Hypocretin receptor type 1 | OX1R_HUMAN | Orexin receptor type 1 | Orexin receptor type 1 (OR 1) | Orexin receptor type 1 (OR-1) | Orexin receptor type 1 (OX1) | Orexin receptor type 1 (OX1R) | Orexin receptor type 1 (OxR1) | Ox1r
Type:
Protein
Mol. Mass.:
47554.50
Organism:
Homo sapiens (Human)
Description:
O43613
Residue:
425
Sequence:
MEPSATPGAQMGVPPGSREPSPVPPDYEDEFLRYLWRDYLYPKQYEWVLIAAYVAVFVVALVGNTLVCLAVWRNHHMRTVTNYFIVNLSLADVLVTAICLPASLLVDITESWLFGHALCKVIPYLQAVSVSVAVLTLSFIALDRWYAICHPLLFKSTARRARGSILGIWAVSLAIMVPQAAVMECSSVLPELANRTRLFSVCDERWADDLYPKIYHSCFFIVTYLAPLGLMAMAYFQIFRKLWGRQIPGTTSALVRNWKRPSDQLGDLEQGLSGEPQPRARAFLAEVKQMRARRKTAKMLMVVLLVFALCYLPISVLNVLKRVFGMFRQASDREAVYACFTFSHWLVYANSAANPIIYNFLSGKFREQFKAAFSCCLPGLGPCGSLKAPSPRSSASHKSLSLQSRCSISKISEHVVLTSVTTVLP
  
Inhibitor
Name:
BDBM79864
Synonyms:
MLS000374324 | N-[3-(2-furanylmethylsulfamoyl)phenyl]-2-phenyl-4-quinolinecarboxamide | N-[3-(2-furfurylsulfamoyl)phenyl]-2-phenyl-cinchoninamide | N-[3-(furan-2-ylmethylsulfamoyl)phenyl]-2-phenyl-quinoline-4-carboxamide | N-[3-(furan-2-ylmethylsulfamoyl)phenyl]-2-phenylquinoline-4-carboxamide | SMR000242241 | cid_3320490
Type:
Small organic molecule
Emp. Form.:
C27H21N3O4S
Mol. Mass.:
483.538
SMILES:
O=C(Nc1cccc(c1)S(=O)(=O)NCc1ccco1)c1cc(nc2ccccc12)-c1ccccc1
Structure:
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