Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3G
Ligand
BDBM80142
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1980±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3G DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3G
Synonyms:
ABC3G_HUMAN | APOBEC3G
Type:
Enzyme Catalytic Domain
Mol. Mass.:
46419.54
Organism:
Homo sapiens (Human)
Description:
gi_13399304
Residue:
384
Sequence:
MKPHFRNTVERMYRDTFSYNFYNRPILSRRNTVWLCYEVKTKGPSRPPLDAKIFRGQVYSELKYHPEMRFFHWFSKWRKLHRDQEYEVTWYISWSPCTKCTRDMATFLAEDPKVTLTIFVARLYYFWDPDYQEALRSLCQKRDGPRATMKIMNYDEFQHCWSKFVYSQRELFEPWNNLPKYYILLHIMLGEILRHSMDPPTFTFNFNNEPWVRGRHETYLCYEVERMHNDTWVLLNQRRGFLCNQAPHKHGFLEGRHAELCFLDVIPFWKLDLDQDYRVTCFTSWSPCFSCAQEMAKFISKNKHVSLCIFTARIYDDQGRCQEGLRTLAEAGAKISIMTYSEFKHCWDTFVDHQGCPFQPWDGLDEHSQDLSGRLRAILQNQEN
Inhibitor
Name:
BDBM80142
Synonyms:
6-Bromo-5-methyl-1H-imidazo[4,5-b]pyridine-2-thiol | 6-bromanyl-5-methyl-1,3-dihydroimidazo[4,5-b]pyridine-2-thione | 6-bromo-5-methyl-1,3-dihydroimidazo[4,5-b]pyridine-2-thione | MLS000554641 | SMR000146758 | cid_5391173
Type:
Small organic molecule
Emp. Form.:
C7H6BrN3S
Mol. Mass.:
244.112
SMILES:
Cc1nc2[nH]c(=S)[nH]c2cc1Br
Structure:
