Reaction Details
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DNA dC->dU-editing enzyme APOBEC-3A
Ligand
BDBM80433
Substrate
n/a
Meas. Tech.
Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay
Temperature
298.15±n/a K
IC50
1760±n/a nM
Comments
extracted
Citation
PubChem, PC Dose Response confirmation of small molecule APOBEC3A DNA Deaminase Inhibitors via a fluorescence-based single-stranded DNA deaminase assay PubChem Bioassay (2011)[AID] More Info.:
Target
Name:
DNA dC->dU-editing enzyme APOBEC-3A
Synonyms:
ABC3A_HUMAN | APOBEC3A | probable DNA dC->dU-editing enzyme APOBEC-3A
Type:
Enzyme Catalytic Domain
Mol. Mass.:
23013.77
Organism:
Homo sapiens (Human)
Description:
gi_21955158
Residue:
199
Sequence:
MEASPASGPRHLMDPHIFTSNFNNGIGRHKTYLCYEVERLDNGTSVKMDQHRGFLHNQAKNLLCGFYGRHAELRFLDLVPSLQLDPAQIYRVTWFISWSPCFSWGCAGEVRAFLQENTHVRLRIFAARIYDYDPLYKEALQMLRDAGAQVSIMTYDEFKHCWDTFVDHQGCPFQPWDGLDEHSQALSGRLRAILQNQGN
Inhibitor
Name:
BDBM80433
Synonyms:
(1,3-dimethyl-1H-imidazol-3-ium-2-yl)methyl methylcarbamate | (1,3-dimethylimidazol-1-ium-2-yl)methyl N-methylcarbamate;iodide | MLS000700479 | N-methylcarbamic acid (1,3-dimethyl-2-imidazol-1-iumyl)methyl ester;iodide | N-methylcarbamic acid (1,3-dimethylimidazol-1-ium-2-yl)methyl ester;iodide | SMR000230276 | cid_15945653
Type:
Small organic molecule
Emp. Form.:
C8H14N3O2
Mol. Mass.:
184.2151
SMILES:
CNC(=O)OCc1n(C)cc[n+]1C
Structure:
